UniKlinik RWTH Aachen

 

 

 

 Website:

  

Contact information:

Institute & address

RWTH Aachen University

Dept. of Pediatrics

Pauwelsstr. 30

52074 Aachen

 

Email: ktenbrock@ukaachen.de

 

Who is who?

PI’s and Key staff members and expertise:

 

Research:

Klaus Tenbrock: Transcriptional regulation of immune system processes, cAMP dependent transcription factors, T cells

Kim Ohl: Role of oxidative stress mediated pathways in immune cells

 

Clinical Pediatric Rheumatology:

Norbert Wagner

Claudia Stollbrink

Dirk Kamitz

Peter Deutz

Klaus Tenbrock

 

Unit website:

https://www.ukaachen.de/kliniken-institute/klinik-fuer-kinder-und-jugendmedizin/forschung-lehre/forschung/transcriptional-regulation-of-the-immune-system.html

 

Short summary research:

Our research focusses on transcriptional mechanisms that regulate immune system processes. In particular we focus on cAMP dependent transcription factors including CREM and CREB in T cells and antigen-presenting cells. We found that they are important for T cell differentiation including TH17 an TH2 pathways and influence IL-2 transcription in systemic lupus erythematosus but also play a role in other autoimmune conditions like juvenile idiopathic arthritis.

In addition we expanded our research to the role of oxidative stress mediated pathways in autoimmunity and inflammation. In particular we focus on Nrf2/Keap1 mediated pathways and their regulation on myeloid cells and regulatory T cells.

  

Funding sources:

DFG

BMBF

Novartis Foundation

Robert Pfleger Foundation

 

 Relevant links:

http://www.ucanr4a.eu/de/bicycle/

https://www.ncbi.nlm.nih.gov/pubmed/?term=Tenbrock+K


  
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